abstract：:Mice lacking dynein arms in the cilia were examined; the strain was obtained by inactivation of dynein heavy chain gene in chromosome 7. The cilia of these mice were examined by electron microscopy and compared to the cilia of random-bred mice. No statistically significant differences or typical disorders in the outer...

journal_title：Bulletin of experimental biology and medicine

authors： Ebsen M,Morgenroth K,Neesen J

更新日期：2004-06-01 00:00:00

abstract：:Oxygen-dependent processes in peripheral blood monocytes were intensified in patients with metabolic cardiovascular syndrome. This was manifested in increased production of O(2)(*-) and NO. Among metabolic factors (cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triacylglycerols...

journal_title：Bulletin of experimental biology and medicine

authors： Suslova TE,Gruzdeva OV,Fedorova TS,Karpov RS

更新日期：2004-05-01 00:00:00

abstract：:We studied the functional role of individual subtypes of muscarinic cholinoceptors in the pathogenesis of neuroleptic parkinsonism in rats. Blockade of M4 receptors prevented the development of extrapyramidal disorders, which was abolished by simultaneous blockade of M2 receptors. The data suggest that various subtype...

journal_title：Bulletin of experimental biology and medicine

authors： Dagaev SG,Fil'ko OA,Kubarskaya LG,Khrabrova AV,Mukovskii LA,Glukhova RI,Sanotskii VI,Dolgo-Saburov VB

更新日期：2004-05-01 00:00:00

abstract：:The effect of epithalamin on circadian rhythms of thymic serum factor titers and melatonin concentrations in the blood of elderly people was studied. Course treatment with epithalamin modulated the rhythm of the thymic endocrine function. The increase in the titer of thymic serum factor at night coincided with the inc...

journal_title：Bulletin of experimental biology and medicine

authors： Labunets IF,Butenko GM,Magdich LV,Korkushko OV,Khavinson VKh,Shatilo VB

更新日期：2004-05-01 00:00:00

abstract：:The mechanism of antiischemic effect of low-energy laser radiation was studied in rats with experimental myocardial infarction taking into consideration the effect of laser on hemoglobin affinity for oxygen and intensity of lipid peroxidation. Low-energy laser irradiation for 15 min in vitro decreased the area of myoc...

journal_title：Bulletin of experimental biology and medicine

authors： Gatsura SV,Gladkikh SP,Titov MN

更新日期：2004-04-01 00:00:00

abstract：:Expression of activation antigens increased in patients with gastrointestinal tumors of various clinical courses. The count of CD25+ and CD71+ lymphocytes was high in patients with favorable course of non-progressive tumors. The increase in the expression of activation markers probably reflects adequate functional act...

journal_title：Bulletin of experimental biology and medicine

authors： Oleinik EK,Shibaev MI,Oleinik VM

更新日期：2004-04-01 00:00:00

abstract：:NAD, cytochrome c, and energostim modulated the fluorescence emission spectrum of trifluoperazine in the solution and in microsomal suspension. The data suggest that NAD and energostim modify structural and conformational characteristics of the dopamine receptor-trifluoperazine complex. These changes probably underlie...

journal_title：Bulletin of experimental biology and medicine

authors： Chikobava EA,Galenko-Yaroshevskii PA,Gurskaya EV,Mamuchishvili IG,Sukoyan GV

更新日期：2004-03-01 00:00:00

abstract：:Age-associated changes in the concentrations of glucose, insulin, and DHEAS in peripheral blood plasma of female rhesus macaques were studied in intact animals and in response to a standard dose of glucose and insulin. Basal levels of insulin and glucose increased, insulin sensitivity and glucose tolerance decreased, ...

journal_title：Bulletin of experimental biology and medicine

authors： Goncharova ND,Vengerin AA,Oganyan TE,Lapin BA

更新日期：2004-03-01 00:00:00

abstract：:We studied the effects of blockade of nicotinic receptors in sympathetic and parasympathetic ganglia (hexamethonium), muscarinic receptors (atropine), and beta1-adrenoceptors (atenolol) on arrhythmogenic activity of endothelin-1 during inhibition of nitric oxide synthesis with Nomega-nitro-L-arginine in NMRI mice. Atr...

journal_title：Bulletin of experimental biology and medicine

authors： Lobanov AV,Rzhevskii DI,Korshunov VA,Murashev AN

更新日期：2004-02-01 00:00:00

abstract：:We studied the effects of selective delta-opiate receptor agonists and antagonists on the phosphoinositide pathway in lymphocytes from healthy donors and patients with diabetes mellitus. The test compounds probably play a role in changes in the sensitivity to pharmacological substances binding to delta-opiate receptor...

journal_title：Bulletin of experimental biology and medicine

authors： Agadjanov MI,Vartanian GS,Tadevosyan YV,Batikyan TB,Agadjanova EM

更新日期：2004-02-01 00:00:00

abstract：:We carried out a retrospective immunohistochemical study of Ki-67, PCNA, Bcl-2, BAX, BclX, and VEGF expression in tumors of two groups of breast cancer patients with favorable and unfavorable course of the disease. Considerably enhanced VEGF expression was detected in tumors of patients with early relapses of breast c...

journal_title：Bulletin of experimental biology and medicine

authors： Kushlinskii NE,Orinovskii MB,Gurevich LE,Kazantseva IA,Talaeva ShZh,Shirokii VP,Ermilova VD,Dvorova EK,Ozherelev AS

更新日期：2004-02-01 00:00:00

abstract：:Arginine-vasopressin or arginine-vasotocin hormones introduced into the small intestine are absorbed and exert a hydrosmotic effect. The amount of absorbed antidiuretic hormone increased when it is introduced with intestinal peptidase inhibitor aprotinin. These data attest to the possibility of absorption of pituitary...

journal_title：Bulletin of experimental biology and medicine

authors： Natochin YV,Shakhmatova EI

更新日期：2004-01-01 00:00:00

abstract：:We studied the influence of pretreatment with chemical mildronate analogue sibusol on the course of experimental gastric ulcer in rats. Sibusol produced a protective effects on the stomach and duodenum. ...

journal_title：Bulletin of experimental biology and medicine

authors： Lychkova AE,Savchuk VI,Smirnov VM

更新日期：2004-01-01 00:00:00

abstract：:Study of the expression of type IV collagen by Lewis pulmonary carcinoma cells (PLMG-T, PLMG-M1, PLMG-M2) showed that these cells produce type IV collagen. The expression of type IV collagen in PLMG-T and PLMG-M2 cells approximately 2-fold surpassed that in PLMG-M1 cells. The number of active cells (synthesizing type ...

journal_title：Bulletin of experimental biology and medicine

authors： Gaenko GP,Khaidukov SV,Molotkovskii YG

更新日期：2004-01-01 00:00:00

abstract：:We studied the effect of four conjugated synthetic derivatives of estrone and ethynylestradiol and bis-beta-chloroethylamine-containing substance on activity of plasma membrane enzymes 5'-nucleotidase and N+-K+-ATPase. As differentiated from precursors, estrogen cytostatics decreased activity of plasma membrane enzyme...

journal_title：Bulletin of experimental biology and medicine

authors： Mayatskaya EE,Semeikin AV,Rzheznikov VM,Shimanovskii NL

更新日期：2003-12-01 00:00:00

abstract：:Comparative analysis of the state of the thymus, activity of cell component of the immune system, and open field behavior of Wistar and OXYS rats showed early involution of the thymus in OXYS rats. By morphological picture this involution corresponded to accidental involution and was paralleled by low level of delayed...

journal_title：Bulletin of experimental biology and medicine

authors： Markova EV,Obukhova LA,Kolosova NG

更新日期：2003-12-01 00:00:00

abstract：:Forty patients with severe asthenia were subjected to clinical, neurological, psychometric, and neurophysiologic examination before and after Enerion therapy. Psychoneurophysiological assessment with cognitive evoked potentials P300 and psychometric tests revealed serious impairment of cognitive functions in patients ...

journal_title：Bulletin of experimental biology and medicine

authors： Gordeev SA,Fedotova AV,Vein AM

更新日期：2003-11-01 00:00:00

abstract：:The combined cytostatic effect of doxorubicin and gestagens progesterone, medroxyprogesterone acetate, mecigestone, and butagest on doxorubicin-resistant and doxorubicin-sensitive human breast cancer MCF-7 cells was studied by the MTT assay. On the 6th day of incubation progesterone, medroxyprogesterone acetate, mecig...

journal_title：Bulletin of experimental biology and medicine

authors： Sergeev PV,Semeikin AV,Fedotcheva TA,Samoilikov RV,Kamernitskii AV,Levina IS,Rzheznikov VM,Grinenko GS,Korystov YN,Ermakova NV,Shaposhnikova VV,Shimanovskii NL

更新日期：2003-11-01 00:00:00

abstract：:Our findings indicate that expression of matrix metalloproteinase-2 is an important prognostic marker of invasive potential of pancreatic tumors. Expression of this marker in neuroendocrine tumors (particularly in gastrinomas) can be used as a differential diagnostic criterion characterizing more malignant phenotype o...

journal_title：Bulletin of experimental biology and medicine

authors： Gurevich LE

更新日期：2003-11-01 00:00:00

abstract：:Non-pulsed optical density of the small intestine was studied in 32 dogs and the results were compared with the data of angiotensometry and pulsomotorography. New regularities of blood circulation in the small intestine were detected: more than half of the total volume specific blood flow in the intestinal tissue is n...

journal_title：Bulletin of experimental biology and medicine

authors： Zhizhin FS,Tochilov SL,Chuchkov VM

更新日期：2003-11-01 00:00:00

abstract：:Chronic administration of neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (30 mg/kg) to C57BL/6 mice caused death of all animals within 7 days. Dipeptide analog of neurotensin active site injected with this neurotoxin protected the mice from death even after 2-week intoxication. When younger mice and lower dos...

journal_title：Bulletin of experimental biology and medicine

authors： Lutsenko VK,Vukolova MN,Kucheryanu VG,Gudasheva TA

更新日期：2003-10-01 00:00:00

abstract：:Crossbred CC57BR/Mv mice inherited tryptophan oxygenase gene and predisposition to alcohol consumption from parent BALB/c and C57BL mice, respectively. In CC57BR/Mv mice no relationships were found between alcohol consumption, tryptophan oxygenase activity, and single nucleotide substitutions in intron 6 of the TDO2 g...

journal_title：Bulletin of experimental biology and medicine

authors： Kaledin VI,Klimova NV,Vasil'ev GV,Ivanova EA,Vasil'eva ED,Il'nitskaya SI

更新日期：2003-10-01 00:00:00

abstract：:Comparative analysis of the efficiency of PCR and microbiological methods for deciphering of the etiological structure of non-nosocomial pneumonias demonstrated the diagnostic significance of detecting Streptococcus pneumoniae DNA in the blood, but not sputum. Mechanisms of penetration of S. pneumoniae into the blood ...

journal_title：Bulletin of experimental biology and medicine

authors： Artemova LV,Beskhlebnaya VA,Ezhova LG,Kirillov MY,Kravtsov EG,Dalin MV

更新日期：2003-10-01 00:00:00

abstract：:Intraleukocytic microbicidal activity of blood neutrophilic granulocytes in cows increased with increasing the term of pregnancy, decreased over the first 2 days after labor, and increased again in the follow-up period. Activity of microbicidal systems markedly decreased after labor, especially in the winter-spring pe...

journal_title：Bulletin of experimental biology and medicine

authors： Gugushvili NN

更新日期：2003-09-01 00:00:00

abstract：:Enzyme immunoassay of the serum neurospecific antigens (gliofibrillar acid protein and neurospecific enolase) was used for evaluation of the resistance of the blood-brain barrier in Wistar rats with perinatal hypoxia and ischemia of the CNS. Perinatal hypoxia and ischemia of the CNS was modeled by two methods: ligatio...

journal_title：Bulletin of experimental biology and medicine

authors： Chekhonin VP,Lebedev SV,Dmitrieva TB,Blinov DV,Gurina OI,Semenova AV,Volodin NN

更新日期：2003-09-01 00:00:00

abstract：:Morphological study of allotransplants of rat embryonic neocortex 14-18 months after transplantation into the neocortex, lateral cerebral ventricle, and sciatic nerve of adult animals revealed death of nerve and glial cells in the delayed postoperation period independently on the site of transplantation. After heterot...

journal_title：Bulletin of experimental biology and medicine

authors： Petrova ES,Otellin VA

更新日期：2003-09-01 00:00:00

abstract：:Secretion and synthesis of vasopressin was studied in adult male Wistar rats receiving lipopolysaccharide in a dose of 250 microg/100 g body weight and subjected to moderate osmotic stimulation (2% NaCl perorally for 6 days). Lipopolysaccharide stimulated secretion of vasopressin into the blood. It should be emphasize...

journal_title：Bulletin of experimental biology and medicine

authors： Liskina EB,Grinevich VV,Volkova OV,Akmaev IG

更新日期：2003-08-01 00:00:00

abstract：:We studied the effects of various natural preparations, including extracts of Siberian ginseng, Rhodiola rosea, bergenia, and ginseng and pantohematogen on erythropoiesis under conditions of conflict situation. The test preparations were divided into 2 groups depending on their modulatory effect on intensified erythro...

journal_title：Bulletin of experimental biology and medicine

authors： Provalova NV,Skurikhin EG,Pershina OV,Minakova MY,Suslov NI,Dygai AM

更新日期：2003-08-01 00:00:00

abstract：:Location of cathepsin D and elastase in rat uterus was studied by electron-histochemical method. Activities of both proteinases in the myometrium was detected in lysosomes of smooth-muscle cells, macrophages, and fibroblasts. ...

journal_title：Bulletin of experimental biology and medicine

authors： Ryvnyak VV,Gudumak VS,Dulgieru OF

更新日期：2003-08-01 00:00:00

abstract：:The relative content of myocyte-active factors and endogenous muscarinic receptor blocker in the blood increased, while the concentration of endogenous beta-adrenoceptor sensitizer decreased in coronary patients with a history of acute myocardial infarction. Physical training produced a therapeutic effect, normalized ...

journal_title：Bulletin of experimental biology and medicine

authors： Tsirkin VI,Nozdrachev AD,Sizova EN,Mal'chikova SV,Gulyaeva SF

更新日期：2003-07-01 00:00:00

abstract：:We studied the mechanisms of combined action of clonidine and local anesthetics amethocaine and imidazo-benzimidazole derivative RU-1117. In contrast to amethocaine, RU-1117 in therapeutic concentrations binds to imidazoline receptors and, to a lesser extent, to alpha(2A)-adrenoceptors on human platelets. Clonidine an...

journal_title：Bulletin of experimental biology and medicine

authors： Ponomarev VP,Galenko-Yaroshevskii AP,Dukhanin AS,Anisimova VA

更新日期：2003-07-01 00:00:00

abstract：:Human embryonic myogenic precursors were transplanted into muscles of mdx mice with hereditary dystrophin-deficient muscular dystrophy. Transplantation induced the synthesis of human dystrophin. The number of dystrophin-positive fibers progressively decreased, however, some of them were preserved even 5 months after t...

journal_title：Bulletin of experimental biology and medicine

authors： Yarygin VN,Sukhikh GT,Sitnikov VF,Stenina MA,Kuznetsov AB,Poltavtseva RA,Krivov LI,Voevodin DA,Savchuk VI,Revishchin AV,Korochkin LI,Aleksandrova MA

更新日期：2003-07-01 00:00:00

abstract：:The content of hemopoietic precursors in the bone marrow, its morphological composition, production of hemopoietic growth factors by cells of the hemopoietic microenvironment, erythropoietic activity, and plasma content of endogenous erythropoietin were studied in CBA/CaLac mice with hypoplasia of hemopoiesis induced ...

journal_title：Bulletin of experimental biology and medicine

authors： Dygai AM,Zhdanov VV,Simanina EV,Gur'yantseva LA,Udut EV,Khrichkova TY,Kirienkova EV,Epstein OI,Gol'dberg ED

更新日期：2003-06-01 00:00:00

abstract：:The effects of glucocorticoids on monocyte morphology and function in vitro and the results of high-dose budesonide therapy in patients with non-severe bronchial asthma were analyzed. Before therapy with inhalation glucocorticosteroid (budesonide) characteristics of blood monocytes and the effects of different concent...

journal_title：Bulletin of experimental biology and medicine

authors： Terpigorev SA,Il'chenko VA,Vasilenko IA,Slinchenko OI,Stotskaya TV,Markina TR,Paleev NR

更新日期：2003-06-01 00:00:00

abstract：:The hypolipidemic effect of Kwai, a preparation based on garlic powder (Allium sativum), depended on the initial content of cholesterol and/or triglycerides. This effect was most pronounced in patients with coronary heart disease with initial cholesterol >7.0 mmol/liter and triglyceride >1.92 mmol/liter. After treatme...

journal_title：Bulletin of experimental biology and medicine

authors： Chernyad'eva IF,Shil'nikova SV,Rogoza AN,Kukharchuk VV

更新日期：2003-05-01 00:00:00

abstract：:We studied expression of Flt-1 and Flk-1 receptors on tumor cells obtained from 83 patients with locally advanced breast cancer after neoadjuvant chemotherapy. The mean period of observations was 32.3 months. The median recurrence-free survival periods for Flt-1(+) and Flt-1(-) patients were 55 and 32 months, respecti...

journal_title：Bulletin of experimental biology and medicine

authors： Zhukova LG,Zhukov NV,Lichinitser MR

更新日期：2003-05-01 00:00:00

abstract：:In acute experiments on cats neural inotropic and lusitropic reactions of the heart to enhancement of pre- and afterload were assessed by changes in contractility and relaxation indices, which were preliminary chosen for their maximum specificity and sensitivity. The control cardiac responses to increased pre- and aft...

journal_title：Bulletin of experimental biology and medicine

authors： Alipov NN,Sokolov AV,Trubetskaya LV,Kuznetsova TE

更新日期：2003-04-01 00:00:00

abstract：:T cells were most sensitive to cyclophosphamide in DBA/2 mice, while in C57Bl/6 mice both T and B cells were sensitive. The formation of antibody-producing cells and the production of specific antibodies were delayed in DBA/2 mice immunized after pretreatment with antitumor drug. Accumulation of antibody-producing cel...

journal_title：Bulletin of experimental biology and medicine

authors： Masnaya NV,Churin AA,Borsuk OS,Sherstoboev EY

更新日期：2003-04-01 00:00:00

abstract：:A course of ascovertin therapy reduced manifestations of perifocal inflammation and atresia of growing follicles, corrected vascular disorders and changes in the tissue volume ratios outside the necrotic zone after monopolar coagulation of the ovaries in rats. The drug prevented the increase in blood viscosity, erythr...

journal_title：Bulletin of experimental biology and medicine

authors： Logvinov SV,Plotnikov MB,Tikhonovskaya OA,Bukharina IY,Maslov MY,Petrova MS

更新日期：2003-04-01 00:00:00

abstract：:Changes in blood pressure and sympathetic nerve activity induced by local injection of endothelin-1 into the rostroventrolateral medulla were studied in narcotized stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive WKY rats. Endothelin-1 produced similar biphasic response in both rat strains: a tran...

journal_title：Bulletin of experimental biology and medicine

authors： Ponomareva TI,Khokhlova ON,Tukhovskaya EA,Murashov AM

更新日期：2003-03-01 00:00:00